Mouse models Content

Resident T-Cells Key to Salmonella Immunity

Andy Fell — April 17, 2023 - 2:47pm

Salmonella infections cause about a million deaths a year worldwide, and there is an urgent need for better vaccines for both typhoid fever and non-typhoidal Salmonella disease. New work from researchers at the �ٺ��Ƶ School of Veterinary Medicine shows how memory T cells, crucial for a vaccine that induces a powerful immune response, can be recruited into the liver in a mouse model of Salmonella.

Revealing a Key Process in How the Brain Forms Memories

Andy Fell — March 29, 2023 - 2:00pm

The process by which memories are formed in the hippocampus region of the brain is complex. It relies on a precise choreography of interactions between neurons, neurotransmitters, receptors and enzymes.

NIH Renews Knockout Mouse Project for 3rd Time

Andy Fell — August 15, 2022 - 10:00am

The University of California, Davis, has been awarded just over $12 million from the National Institutes of Health under the third and final five-year phase of the Knockout Mouse Phenotyping Project, or KOMP2. �ٺ��Ƶ is the lead organization in a consortium involving a partnership with The Centre for Phenogenomics in Toronto.

Grant to Create Humanized Mice for HIV Studies

Andy Fell — August 12, 2022 - 2:41pm

Creating a new type of ‘humanized mouse’ that can be infected with HIV is the goal of new project at the Mouse Biology Program of the University of California, Davis. The work is funded with a grant of nearly $500,000 from the National Institutes of Health.

A Map of Mouse Brain Metabolism in Aging

Andy Fell — October 15, 2021 - 4:09pm

The first atlas of metabolites in the mouse brain has been published by a team led by �ٺ��Ƶ researchers. The dataset includes 1,547 different molecules across 10 brain regions in male and female laboratory mice from adolescence through adulthood and into advanced old age. The work is published Oct. 15 in the Nature Communications. The complete dataset is publicly available at https://mouse.atlas.metabolomics.us/.

NIH Grant to Create Humanized Mice Susceptible to COVID-19

Andy Fell — August 03, 2020 - 1:36pm

The National Institutes of Health has awarded a grant of $1.2 million to the Mouse Biology Program at the University of California, Davis, to create mice that are susceptible to the COVID-19 virus, and to distribute them to researchers.

The goal is to create mice that can be used to reproduce human COVID-19 disease, said Kent Lloyd, director of the Mouse Biology Program and professor in the Department of Surgery at the �ٺ��Ƶ School of Medicine.

Popular Painkiller Ibuprofen Affects Liver Enzymes in Mice

Andy Fell — March 11, 2020 - 10:57am

The popular painkiller ibuprofen may have more significant effects on the liver than previously thought, according to new research from the University of California, Davis. The study in laboratory mice also shows marked differences between males and females.

The work is published Feb. 25 in Scientific Reports.

Oxytocin Turns Up the Volume of Your Social Environment

Andy Fell — September 20, 2017 - 9:27am

Before you shop for the “cuddle” hormone oxytocin to relieve stress and enhance your social life, read this: A new study from the University of California, Davis, suggests that sometimes, blocking the action of oxytocin in the brain may be a better option. The results are published online in the journal Biological Psychiatry.