Institute for Psychedelics and Neurotherapeutics Content

�ٺ��Ƶ Researchers Achieve Total Synthesis of Ibogaine

Andy Fell — February 06, 2025 - 10:45am

Ibogaine — a psychoactive plant derivative — has attracted attention for its anti-addictive and anti-depressant properties. But ibogaine is a finite resource, extracted from plants native to Africa like the iboga shrub (Tabernanthe iboga) and the small-fruited voacanga tree (Voacanga africana). Further, its use can lead to irregular heartbeats, introducing safety risks and an overall need to better understand how its molecular structure leads to its biological effects.

Anti-Anxiety and Hallucination-Like Effects of Psychedelics Mediated by Distinct Neural Circuits

Andy Fell — November 14, 2024 - 10:06am

New research suggests that it could be possible to separate treatment from hallucinations when developing new drugs based on psychedelics. The anti-anxiety andhallucination-inducing qualities of psychedelic drugs work through different neural circuits, according to research using a mouse model. The work is published Nov. 15 in Science.

Exploring the Psychedelics Within Us

Andy Fell — October 21, 2024 - 3:00pm

Our bodies are pharmaceutical factories. From the hormones that regulate our blood sugar to the neurotransmitters that act as the body’s natural painkillers, these endogenous — produced within the body — chemicals ensure our functionality and survival.

But did you know that our bodies also naturally produce psychedelics?

In the 1950s, researchers found chemical signatures of N,N-dimethyltryptamine (DMT) in mammalian bodies, including in humans.

New Method Tracks How Psychedelics Affect Neurons in Minutes

Andy Fell — August 05, 2024 - 10:22am

Researchers at the University of California, Davis have developed a rapid, noninvasive tool to track the neurons and biomolecules activated in the brain by psychedelic drugs. The protein-based tool, which is called Ca^2+-activated Split-TurboID, or CaST, is described in research published in Nature Methods.

Institute for Psychedelics and Neurotherapeutics Content

�ٺ���Ƶ Researchers Achieve Total Synthesis of Ibogaine

Anti-Anxiety and Hallucination-Like Effects of Psychedelics Mediated by Distinct Neural Circuits

Exploring the Psychedelics Within Us

New Method Tracks How Psychedelics Affect Neurons in Minutes

�ٺ��Ƶ Researchers Achieve Total Synthesis of Ibogaine